Validated SARS-CoV-2 related structural models of potential drug targets

Rational drug design against emerging threats depends on well-established current methodology worked out by structural biology to provide accurate structure models of the macromolecular drug targets. In the current COVID-19 crisis, the structural biological community has responded at once, presenting in rapid succession structure models of CoV-2 proteins and depositing them in the Protein Data Bank (PDB), without time embargo and before publication. Since the structures from the first-line research are produced in an accelerated mode, there is an elevated chance of mistakes and errors. Here, we provide a source of carefully validated PDB models of CoV-2 proteins, with the aim of helping the biomedical community to establish a validated database.

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Our database currently contains information about 777 SARS-CoV-2 protein structures and 26 additional structures of other coronaviruses. Use the filters below to select rows with attributes of interest. Next to each filter value, the number of shown/total structures from the group is displayed. Multiple values can be selected across multiple panes. To select more than one value within a single search pane, press and hold Ctrl or Shift when selecting filters. By default, the Non-PanDDA structures filter is turned on. To show PanDDA structures, just click on the blue filter in the Presets pane to unselect it, or use the Clear All button. Text search can be performed using the search box on the left below the filters.